Research in the Pellois lab is currently focused on the following topics:
development of reagents that can deliver macromolecules into live cells efficiently and safely
use of such delivery approaches to deliver proteins into live cells so as to manipulate and investigate cellular processes
development of peptide-based photosensitizers for the light-induced inactivation of drug-resistant bacteria
Each of these projects involves a combination of chemistry, biochemistry and cell biology. We typically study how certain peptides interact with human or bacterial cells, investigate their mechanism of action at a molecular level, and design new compounds with improved activities based on this knowledge.