Research in the Pellois lab is currently focused on the following topics:
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development of reagents that can deliver macromolecules into live cells efficiently and safely
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use of such delivery approaches to deliver proteins into live cells so as to manipulate and investigate cellular processes
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development of peptide-based photosensitizers for the light-induced inactivation of drug-resistant bacteria
Each of these projects involves a combination of chemistry, biochemistry and cell biology. We typically study how certain peptides interact with human or bacterial cells, investigate their mechanism of action at a molecular level, and design new compounds with improved activities based on this knowledge.